The most serious adverse effect is its depression of the bone marrow. Bone marrow hypoplasia, including aplastic anemia and death, has been reported following local application of Chloramphenicol. Allergic reactions due to individual hypersensitivity, stinging, itching, urticaria, angioneurotic edema and allergic lid eczema also occur. Blurred vision may occur after application of ophthalmic ointment.